Kathy Sierra has a
fascinating blog entry where she talks about the negative effects of boring work environments on your actual brain chemistry.
You always knew that dull, boring cubicles could suck the joy out of work, but now there's evidence that they can change your brain. Not mentally or emotionally, no, we're talking physical structural changes.
What the research suggests is that in unstimulating, unenriched, stressful environments, the brain STOPS producing new neurons